SE-lncRNAs in Cancer: Classification, Subcellular Localisation, Function and Corresponding TFs

J Cell Mol Med. 2024 Dec;28(24):e70296. doi: 10.1111/jcmm.70296.

Abstract

Emerging evidence highlights certain long noncoding RNAs (lncRNAs) transcribed from or interacting with super-enhancer (SE) regulatory elements. These lncRNAs, known as SE-lncRNAs, are strongly linked to cancer and regulate cancer progression through multiple interactions with downstream targets. The expression of SE-lncRNAs is controlled by various transcription factors (TFs), and dysregulation of these TFs can contribute to cancer development. In this review, we discuss the characteristics, classification and subcellular distribution of SE-lncRNAs and summarise the role of key TFs in the transcription and regulation of SE-lncRNAs. Moreover, we examine the distinct functions and potential mechanisms of SE-lncRNAs in cancer progression.

Keywords: ECM remodelling; SE‐lncRNAs; cancer; subcellular location; transcriptional regulation.

Publication types

  • Review

MeSH terms

  • Animals
  • Enhancer Elements, Genetic / genetics
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neoplasms* / genetics
  • Neoplasms* / metabolism
  • Neoplasms* / pathology
  • RNA, Long Noncoding* / classification
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / metabolism
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism

Substances

  • RNA, Long Noncoding
  • Transcription Factors