Granulocyte Colony-Stimulating Factor-Associated Aortitis Unveiled by 18F-FDG PET/CT

Hélène Artigou; Hervé Foka Tichoue; Cindy Marques; Frédéric Charlotte; P A Vion; Aurélie Kas; Laura Rozenblum

doi:10.1097/RLU.0000000000005580

Granulocyte Colony-Stimulating Factor-Associated Aortitis Unveiled by 18F-FDG PET/CT

Clin Nucl Med. 2024 Dec 18. doi: 10.1097/RLU.0000000000005580. Online ahead of print.

Authors

Hélène Artigou¹, Hervé Foka Tichoue², Cindy Marques³, Frédéric Charlotte⁴, P A Vion¹, Aurélie Kas, Laura Rozenblum

Affiliations

¹ From the Department of Nuclear Medicine, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.
² University Cancer Institut, Sorbonne University, Department of Medical Oncology, Pitié-Salpétrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
³ Internal Medicine and Clinical Immunology, Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, Sorbonne University, Paris, France.
⁴ Pathology Department, Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, Sorbonne Universiy, Paris, France.

PMID: 39690506
DOI: 10.1097/RLU.0000000000005580

Abstract

In oncology, G-CSF (granulocyte colony-stimulating factor) is often administered to counteract chemotherapy-induced neutropenia. Recent studies have highlighted a significant side effect, G-CSF-associated aortitis, with an incidence of ~0.4%. Identification of this condition's imaging characteristics is crucial for nuclear medicine specialists, given its substantial impact on clinical decision-making. It is notably prevalent in the follow-up of gynecologic malignancies and lymphoma. We detail a case of G-CSF-related aortitis in a metastatic ovarian cancer patient, diagnosed by increased 18F-FDG uptake in the aortic arch on PET/CT, confirmed by contrast-enhanced CT and biopsy, which regressed spontaneously in under 5 weeks without corticosteroid treatment.