Invasive Aspergillosis With Multiple Locations, Mediastinitis, and Cardiac Invasion

Anil Kumar Choudhary; Manphool Singhal; Navjyot Kaur; Yamasandi Siddegowda Shrimanth; Manish Shaw; Suraj Kumar; Nishtha Ahuja; Aditya Kumar; Manoj Kumar Rohit

doi:10.1016/j.jaccas.2024.102770

Invasive Aspergillosis With Multiple Locations, Mediastinitis, and Cardiac Invasion

JACC Case Rep. 2024 Dec 4;29(23):102770. doi: 10.1016/j.jaccas.2024.102770.

Authors

Anil Kumar Choudhary¹, Manphool Singhal², Navjyot Kaur¹, Yamasandi Siddegowda Shrimanth³, Manish Shaw⁴, Suraj Kumar⁵, Nishtha Ahuja⁶, Aditya Kumar⁷, Manoj Kumar Rohit¹

Affiliations

¹ Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
² Department of Radiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
³ Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Mysuru, India.
⁴ Department of Interventional Radiology, NIMSR, Jaipur, India.
⁵ Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁶ Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁷ Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

A 25-year-old man reporting weight loss and constitutional symptoms was empirically treated for tuberculosis. Following acute seizures, the patient underwent cerebral imaging and was diagnosed with multiple nonischemic cerebral lesions. Thoracic imaging revealed fibrosing mediastinitis infiltrating and obscuring the left atrium and left ventricle. Results of a skin nodule biopsy revealed fungal hyphae, and invasive aspergillosis was finally diagnosed.

Keywords: aspergillosis; fibrosing mediastinitis; left atrial mass; thoracic magnetic resonance imaging.

Publication types

Case Reports