An additive opinion to the committee opinion of ASRM and SART on the use of preimplantation genetic testing for aneuploidy (PGT-A)

Norbert Gleicher; David H Barad; Pasquale Patrizio; Sonya Gayete-Lafuente; Andrea Weghofer; Zion Ben Rafael; Shizuko Takahashi; Demián Glujovsky; Ben W Mol; Raoul Orvieto

doi:10.1007/s10815-024-03318-z

An additive opinion to the committee opinion of ASRM and SART on the use of preimplantation genetic testing for aneuploidy (PGT-A)

J Assist Reprod Genet. 2024 Dec 18. doi: 10.1007/s10815-024-03318-z. Online ahead of print.

Authors

Norbert Gleicher^{1

2

3

4}, David H Barad^{5

6}, Pasquale Patrizio^{1

7}, Sonya Gayete-Lafuente¹, Andrea Weghofer^{1

4}, Zion Ben Rafael⁸, Shizuko Takahashi⁹, Demián Glujovsky¹⁰, Ben W Mol¹¹, Raoul Orvieto^{12

13}

Affiliations

¹ Center for Human Reproduction (CHR), New York, NY, USA.
² Foundation for Reproductive Medicine, New York, NY, USA.
³ Laboratory of Synthetic Embryology, Rockefeller University, New York, NY, USA.
⁴ Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
⁵ Center for Human Reproduction (CHR), New York, NY, USA. [email protected].
⁶ Foundation for Reproductive Medicine, New York, NY, USA. [email protected].
⁷ Department of Obstetrics, Gynecology and Reproductive Sciences, University of Miami, Miller School of Medicine, Miami, FL, USA.
⁸ Department of Obstetrics, Gynecology, and IVF, Laniado Medical Center, Netanya, Israel.
⁹ Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, Singapore, Singapore.
¹⁰ Cegyr (Eugin Group), Buenos Aires, Argentina.
¹¹ Department of Obstetrics and Gynecology, Monash University, Melbourne, Australia.
¹² Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
¹³ Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

PMID: 39693036
DOI: 10.1007/s10815-024-03318-z

Abstract

After over 20 years of progressively increasing clinical utilization of PGT-A (and its precursors), the American Society for Reproductive Medicine (ASRM) and its daughter society, the Society for Assisted Reproduction (SART), for the first time published a committee opinion clearly acknowledging that "the value of PGT-A as a routine screening test for patients undergoing in vitro fertilization (IVF) has not been demonstrated." This statement is timely and welcome but requires some additions and raises some new questions, among those why, if PGT-A in a general population does not improve IVF cycle outcomes, the routine clinical utilization of PGT-A should continue.

Keywords: Aneuploidy; Embryos; In vitro fertilization (IVF); Preimplantation genetic testing for aneuploidy (PGT-a); Reproductive medicine; Reproductive science.