Meeting metformin again for the first time

Sci Adv. 2024 Dec 20;10(51):eadu7436. doi: 10.1126/sciadv.adu7436. Epub 2024 Dec 18.

Abstract

New evidence convincingly shows that metformin, a drug that reduces circulating glucose, acts by inhibiting mitochondrial complex I.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / drug therapy
  • Electron Transport Complex I / antagonists & inhibitors
  • Electron Transport Complex I / metabolism
  • Humans
  • Hypoglycemic Agents* / pharmacology
  • Hypoglycemic Agents* / therapeutic use
  • Metformin* / pharmacology
  • Metformin* / therapeutic use
  • Mitochondria / drug effects
  • Mitochondria / metabolism

Substances

  • Metformin
  • Hypoglycemic Agents
  • Electron Transport Complex I