Migraine Management in Japan: Current Approaches and Science Narrative Including an Evidence-based Review

Intern Med. 2024 Dec 19. doi: 10.2169/internalmedicine.4846-24. Online ahead of print.

Abstract

Migraine is a prevalent and highly disabling neurological disorder. Recent progress in neuroscientific research has contributed to the development of new therapies for migraine, including triptans, ditans, calcitonin gene-related peptide (CGRP) antagonists, and CGRP-related monoclonal antibodies. Noninvasive neuromodulation devices have also been developed. We herein review the recent advances in research and the current standard of management for migraine patients.

Keywords: calcitonin gene-related peptide (CGRP); neuromodulation; pharmacotherapy.