[A case of synchronous mediastinal and pineal germ cell tumors]

J Liu; W Zhao; X S Wang; M Jin; C H Chen; H W Jia; L B Fu; T Yu; Y Su

doi:10.3760/cma.j.cn112140-20240502-00305

[A case of synchronous mediastinal and pineal germ cell tumors]

Zhonghua Er Ke Za Zhi. 2025 Jan 2;63(1):87-89. doi: 10.3760/cma.j.cn112140-20240502-00305.

[Article in Chinese]

Authors

J Liu¹, W Zhao¹, X S Wang¹, M Jin¹, C H Chen², H W Jia³, L B Fu⁴, T Yu⁵, Y Su¹

Affiliations

¹ Department of Medical Oncology, Pediatric Oncology Center,Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, National Key Clinical Discipline of Pediatric Oncology,Laboratory for Clinical Medicine, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing100045, China.
² Department of Thoracic Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing100045, China.
³ Department of Radiotherapy, Beijing You Anmen Hospital, Beijing100069, China.
⁴ Department of Pathology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing100045, China.
⁵ Medical Imaging Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing100045, China.

PMID: 39694569
DOI: 10.3760/cma.j.cn112140-20240502-00305

Abstract

患儿，男，13岁，因“间断胸痛伴右侧背部、上臂痛2周”就诊。影像学提示前上纵隔和松果体区占位。外周血和脑脊液人绒毛膜促性腺激素均升高。外周血及脑脊液甲胎蛋白正常。纵隔占位病理诊断精原细胞瘤。颅内占位根据影像学特点、血和脑脊液甲胎蛋白正常、脑脊液人绒毛膜促性腺激素轻度升高临床诊断颅内生殖细胞肿瘤，生殖细胞瘤可能性大。经化疗、纵隔肿物切除术、纵隔和全脑放疗，随访11个月完全缓解。.

Publication types

Case Reports

MeSH terms

Adolescent
Brain Neoplasms / diagnosis
Brain Neoplasms / pathology
Brain Neoplasms / therapy
Chorionic Gonadotropin / blood
Humans
Magnetic Resonance Imaging
Male
Mediastinal Neoplasms* / diagnosis
Mediastinal Neoplasms* / pathology
Mediastinal Neoplasms* / therapy
Neoplasms, Germ Cell and Embryonal* / diagnosis
Neoplasms, Germ Cell and Embryonal* / pathology
Neoplasms, Germ Cell and Embryonal* / therapy
Neoplasms, Multiple Primary / diagnosis
Neoplasms, Multiple Primary / pathology
Neoplasms, Multiple Primary / therapy
Pineal Gland* / pathology
Pinealoma* / diagnosis
Pinealoma* / pathology
Pinealoma* / therapy
Seminoma / diagnosis
Seminoma / pathology
Seminoma / therapy
Tomography, X-Ray Computed
alpha-Fetoproteins / analysis

Substances

Chorionic Gonadotropin
alpha-Fetoproteins