7T MRI as a powerful tool to detect small and medium size vessel CNS vasculitis

Angelika Hoffmann; Willian Almiri; Pasquale Mordasini; Alexandrine Bähler; David J Seiffge; Martina B Göldlin; Eugen Jäger; Ioan-Paul Muresan; Lisa Christ; Mirjam R Heldner; Roland Wiest; Piotr Radojewski

doi:10.3174/ajnr.A8627

7T MRI as a powerful tool to detect small and medium size vessel CNS vasculitis

AJNR Am J Neuroradiol. 2024 Dec 18:ajnr.A8627. doi: 10.3174/ajnr.A8627. Online ahead of print.

Affiliation

¹ Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland (A.H., W.A., A.B.,R.W., P.R.), Department of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland (P.M.), Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland (D.J.S.,M.G., M.R.H.), Institute of Radiology, Clinic Maennedorf, Maennedorf, Zurich, Switzerland (E.J.), Department of Neurology, RHNe, Hôpital Pourtalès, Neuchâtel, Switzerland (P.M.), Department of Rheumatology, Inselspital, University of Bern, Bern, Switzerland (L.C.) Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland (R.W., P.R.).

PMID: 39694614
DOI: 10.3174/ajnr.A8627

Abstract

Imaging can help to diagnose CNS vasculitis. Yet so far, no imaging studies of CNS vasculitis at 7T are available. We share our experience of vessel wall imaging (VWI) at 7T in patients with suspected vasculitis. All included patients (n=45) underwent a clinically approved 7T MRI comprising high resolution arterial TOF angiography as well as high resolution VWI with T1SPACE and T1SE acquired pre-and post-contrast. 23 patients showed negative and 22 patients positive VWI at 7T. Ten out of 22 7T VWI positive cases were suggestive of vasculitis with 9 patients showing VWI of large and medium size vessels and one patient VWI of small vessels. Small vessel vasculitis was only depicted with 7T VWI, but not 3T VWI. Our work demonstrates that diagnosing CNS vasculitis, especially small vessel vasculitis, is feasible at 7T and highlights the potential of high field VWI encouraging further studies in this field.ABBREVIATIONS: FS= fat-saturated, SNR= signal-to-noise ratio, VWI= vessel wall imaging.