NMR resonance assignment of a ligand-binding domain of ephrin receptor A2

Ephrin receptors regulate intercellular communication and are thus involved in tumor development. Ephrin receptor A2 (EphA2), in particular, is overexpressed in a variety of cancers and is a proven target for anti-cancer drugs. The N-terminal ligand-binding domain of ephrin receptors is responsible for the recognition of their ligands, ephrins, and is directly involved in receptor activation. Here, we report on the complete ¹H, ¹⁵N and ¹³C NMR chemical shift assignment of EphA2 ligand binding domain that provides the basis for NMR-assisted drug design.