Prognostic Value of Human Epididymis Protein 4 in Acute Myocardial Infarction

Yi Tang; Wen-Yu Zhu; Si-Ling Peng; Shuai Huang; Qiu-Ni Zhao; Si-Yuan Tan; Zi-Hui Yin; Yan Zhang; Jian-Qiang Peng; Hong-Wei Pan

doi:10.2147/IJGM.S470399

Prognostic Value of Human Epididymis Protein 4 in Acute Myocardial Infarction

Int J Gen Med. 2024 Dec 14:17:6243-6251. doi: 10.2147/IJGM.S470399. eCollection 2024.

Authors

Yi Tang^#¹, Wen-Yu Zhu^#², Si-Ling Peng^#², Shuai Huang^#², Qiu-Ni Zhao³, Si-Yuan Tan², Zi-Hui Yin², Yan Zhang¹, Jian-Qiang Peng¹, Hong-Wei Pan¹

Affiliations

¹ Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, 410005, People's Republic of China.
² Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Hunan Normal University, Changsha, 410005, People's Republic of China.
³ Department of Anesthesia Operation, Maternal and Child Health Care Hospital of Hunan, Changsha, 410000, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: To investigate the prognostic value of human epididymis protein 4 (HE4) in patients with acute myocardial infarction (AMI).

Patients and methods: A total of 212 consecutive patients diagnosed with AMI in the Department of Cardiovascular Medicine of Hunan Provincial People's Hospital from June 2020 to May 2021 were enrolled. We determined plasma HE4 levels at baseline. The patients were followed up regularly and the occurrence of major adverse cardiac events (MACE) was recorded after discharge.

Results: After a mean follow-up period of 242 (159-427) days, 67 patients had MACE. Multivariate Cox regression analysis showed that HE4 was an independent predictor of MACE in patients with AMI [HR = 1.004 (1.002-1.007), P = 0.002]. Kaplan-Meier survival curves showed that patients with HE4 levels > 532.9 pmol/L had higher MACE compared with patients with ≤ 532.9 pmol/L HE4 levels (HR=4.044, 95% CI 2.373-6.890, P <0.001). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of HE4 for predicting MACE was 0.734 (95% CI: 0.669-0.792, P < 0.001).

Conclusion: Human epididymis protein 4 (HE4) might be a novel biomarker for predicting the prognosis of patients with AMI.

Keywords: acute myocardial infarction; biomarkers; human epididymis protein.

Grants and funding

This work was supported by grants from the National Clinical Key Specialty Construction Project Cardiovascular Department (Cardiopulmonary Function Rehabilitation Direction) (Z2023123), Renshu Fund project of Hunan Provincial People’s Hospital (RS2022A12), Key Project of Hunan provincial science and technology innovation (2020SK1013) and Hunan Provincial Health Commission Fund (202214013647).