Long-term chronic infection of a young immunocompromised patient by the SARS-CoV-2 P.2 VOI

Rev Inst Med Trop Sao Paulo. 2024 Dec 6:66:e69. doi: 10.1590/S1678-9946202466069. eCollection 2024.

Abstract

An immunocompromised patient was infected by the SARS-CoV-2 variant of interest named Zeta (P.2) in February 2021. More than one year later, he suffered from symptomatic COVID-19 and sequencing revealed the same variant, which accumulated 23 substitutions. This case illustrates intra-host evolution of a particular SARS-CoV-2 variant, highlighting the importance of genomic surveillance of immunocompromised patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • COVID-19* / immunology
  • Chronic Disease
  • Humans
  • Immunocompromised Host*
  • Male
  • SARS-CoV-2* / genetics
  • SARS-CoV-2* / immunology

Supplementary concepts

  • SARS-CoV-2 variants

Grants and funding

This study was funded by DASA ESG, KFWDEG Bank grant Nº G0512 and CNPQ CABBIO grant Nº 423857/2021-5. PCR: CNPq productivity research fellowship 311759/2022-0; MMS: CNPq productivity research fellowship 313403/2018-0; CMR: CNPq 402794/2020-6 and productivity research fellowship 306921/2023-5; CSA: Fapesp 2021/13419-6