Unveiling the hidden network of STING's subcellular regulation

Xiaoqi Sun; Brian D Brown

doi:10.1016/j.cels.2024.11.014

Unveiling the hidden network of STING's subcellular regulation

Cell Syst. 2024 Dec 18;15(12):1153-1155. doi: 10.1016/j.cels.2024.11.014.

Authors

Xiaoqi Sun¹, Brian D Brown²

Affiliations

¹ Icahn Genomics Institute (IGI), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Immunology & Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: [email protected].
² Icahn Genomics Institute (IGI), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Immunology & Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: [email protected].

PMID: 39701032
DOI: 10.1016/j.cels.2024.11.014

Abstract

A new study deconvolutes the systems-level control of the cGAS-STING pathway and identifies many novel regulators of STING biology. This was made possible by optical pooled screening (OPS), which enables high-dimensional imaging of millions of gene-edited cells, showcasing the future of CRISPR screening.

MeSH terms

Animals
Humans
Membrane Proteins* / genetics
Membrane Proteins* / metabolism
Nucleotidyltransferases / genetics
Nucleotidyltransferases / metabolism
Signal Transduction*

Substances

Membrane Proteins
STING1 protein, human
Nucleotidyltransferases
cGAS protein, human