Complexity demands more flexibility and the prefrontal cortex has an answer

Talha Soluoku; James M Hyman

doi:10.1016/j.neuron.2024.11.017

Complexity demands more flexibility and the prefrontal cortex has an answer

Neuron. 2024 Dec 18;112(24):3989-3991. doi: 10.1016/j.neuron.2024.11.017.

Authors

Talha Soluoku¹, James M Hyman²

Affiliations

¹ University of Nevada, Las Vegas, Interdisciplinary Program in Neuroscience, Las Vegas, NV 89154-1003, USA.
² University of Nevada, Las Vegas, Interdisciplinary Program in Neuroscience, Las Vegas, NV 89154-1003, USA; University of Nevada, Las Vegas, Department of Psychology, Las Vegas, NV 89154-1003, USA. Electronic address: [email protected].

PMID: 39701040
DOI: 10.1016/j.neuron.2024.11.017

Abstract

Cognitive flexibility allows us to adapt our behavior to keep up with a changing environment. In this issue of Neuron, Mugan and colleagues¹ manipulate the complexity of an environment to demonstrate how the medial prefrontal cortex controls a cognitive flexibility circuit featuring the dorsolateral striatum and hippocampus.

MeSH terms

Animals
Cognition* / physiology
Hippocampus / physiology
Humans
Prefrontal Cortex* / physiology