Macrophages in inflammatory skin diseases and skin tumors

Si-Han Liu; Jie Zhang; Ya-Gang Zuo

doi:10.3389/fimmu.2024.1430825

Macrophages in inflammatory skin diseases and skin tumors

Front Immunol. 2024 Dec 5:15:1430825. doi: 10.3389/fimmu.2024.1430825. eCollection 2024.

Authors

Si-Han Liu¹, Jie Zhang¹, Ya-Gang Zuo¹

Affiliation

¹ Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract

Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being the largest immune organ in the human body, presents an intriguing landscape for macrophage research, particularly regarding their roles in inflammatory skin diseases and skin tumors. In this review, we compile the latest research on macrophages in conditions such as atopic dermatitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, rosacea, bullous pemphigoid, melanoma and cutaneous T-cell lymphoma. We aim to contribute to illustrating the pathogenesis and potential new therapies for inflammatory skin diseases and skin tumors from the perspective of macrophages.

Keywords: inflammatory skin diseases; macrophage; pathogenesis; skin tumors; treatment.

Publication types

Review

MeSH terms

Animals
Humans
Inflammation / immunology
Macrophages* / immunology
Skin / immunology
Skin / pathology
Skin Diseases* / immunology
Skin Diseases* / therapy
Skin Neoplasms* / etiology
Skin Neoplasms* / immunology
Skin Neoplasms* / pathology
Skin Neoplasms* / therapy

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from Beijing Natural Science Foundation, grant numbers 7232118; National High Level Hospital Clinical Research Funding, grant number 2022-PUMCH-B-092, and National Key Clinical Specialty Project of China.