DAMNet: Dynamic mobile architectures for Alzheimer's disease

Comput Biol Med. 2024 Dec 20:185:109517. doi: 10.1016/j.compbiomed.2024.109517. Online ahead of print.

Abstract

Alzheimer's disease (AD) presents a significant challenge in healthcare, highlighting the necessity for early and precise diagnostic tools. Our model, DAMNet, processes multi-dimensional AD data effectively, utilizing only 7.4 million parameters to achieve diagnostic accuracies of 98.3 % in validation and 99.9 % in testing phases. Despite a 20 % pruning rate, DAMNet maintains consistent performance with less than 0.2 % loss in accuracy. The model also excels in handling 3D (Three-Dimensional) MRI data, achieving a 95.7 % F1 score within 805 s during a rigorous three-fold validation over 200 epochs. Furthermore, we introduce a novel parallel intelligent framework for early AD detection that improves feature extraction and incorporates advanced data management and control. This framework sets a new benchmark in intelligent, precise medical diagnostics, adeptly managing both 2D (Two-Dimensional) and 3D imaging data.

Keywords: 2D and 3D imaging; Alzheimer's disease; DAMNet; Parallel intelligence.