Platelet-mimicking nanoparticles loaded with diallyl trisulfide for Mitigating Myocardial Ischemia-Reperfusion Injury in rats

Yihan Chen; Ling Lin; Lingling Xu; Qiaofeng Jin; Wenpei Fu; Ying Bai; Tian Huang; Tang Gao; Wenqian Wu; Chunyan Xu; Jing Wang; Li Zhang; Qing Lv; Yali Yang; Mingxing Xie; Xiaoqiu Dong

doi:10.1016/j.colsurfb.2024.114460

Platelet-mimicking nanoparticles loaded with diallyl trisulfide for Mitigating Myocardial Ischemia-Reperfusion Injury in rats

Colloids Surf B Biointerfaces. 2024 Dec 17:248:114460. doi: 10.1016/j.colsurfb.2024.114460. Online ahead of print.

Authors

Yihan Chen¹, Ling Lin², Lingling Xu³, Qiaofeng Jin³, Wenpei Fu³, Ying Bai³, Tian Huang³, Tang Gao³, Wenqian Wu³, Chunyan Xu³, Jing Wang³, Li Zhang⁴, Qing Lv³, Yali Yang⁵, Mingxing Xie⁶, Xiaoqiu Dong⁷

Affiliations

¹ Department of Ultrasonography, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China; Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University School of Medical, Hangzhou, China.
³ Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
⁴ Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China; Shenzhen Huazhong University of Science and Technology Research Institute, China.
⁵ Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. Electronic address: [email protected].
⁶ Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China; Shenzhen Huazhong University of Science and Technology Research Institute, China. Electronic address: [email protected].
⁷ Department of Ultrasonography, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: [email protected].

PMID: 39709937
DOI: 10.1016/j.colsurfb.2024.114460

Abstract

Hydrogen sulfide (H₂S) shows promise in treating myocardial ischemia-reperfusion injury (MIRI), but the challenge of controlled and sustained release hinders its clinical utility. In this study, we developed a platelet membrane-encapsulated mesoporous silica nanoparticle loaded with the H₂S donor diallyl trisulfide (PM-MSN-DATS). PM-MSN-DATS demonstrated optimal encapsulation efficiency and drug-loading content. Comprehensive in vitro and in vivo assessments confirmed the biosafety of PM-MSN-DATS. In vitro, PM-MSN-DATS adhered to inflammation-activated endothelial cells and exhibited targeted accumulation in MIRI rat hearts. In vivo experiments revealed significant reductions in reactive oxygen species (ROS) and myocardial fibrosis area, improving cardiac function. Our findings highlight successfully creating a targeted H₂S delivery system through platelet membrane-coated MSN nanoparticles. This well-designed drug delivery platform holds significant promise for advancing MIRI treatment strategies.

Keywords: Diallyl trisulfide; Hydrogen sulfide; Mesoporous silica nanoparticles; Myocardial ischemia-reperfusion injury; Platelet membrane.