Interaction between ischemia-reperfusion injury and intestinal microecology in organ transplantation and its therapeutic prospects

Front Immunol. 2024 Dec 6:15:1495394. doi: 10.3389/fimmu.2024.1495394. eCollection 2024.

Abstract

Organ transplantation is a vital intervention for end-stage organ failure; however, ischemia-reperfusion injury is a complication of transplantation, affecting the prognosis and survival of transplant recipients. As a complex ecosystem, recent research has highlighted the role of the intestinal microecology in transplantation, revealing its significant interplay with ischemia-reperfusion injury. This review explores the interaction between ischemia-reperfusion injury and intestinal microecology, with a special focus on how ischemia-reperfusion injury affects intestinal microecology and how these microecological changes contribute to complications after organ transplantation, such as infection and rejection. Based on a comprehensive analysis of current research advances, this study proposes potential strategies to improve transplant outcomes, offering guidance for future research and clinical practice.

Keywords: intestinal barrier; intestinal microecology; ischemia-reperfusion injury; microbial therapy; organ transplantation.

Publication types

  • Review

MeSH terms

  • Animals
  • Gastrointestinal Microbiome*
  • Graft Rejection / immunology
  • Humans
  • Intestines
  • Organ Transplantation* / adverse effects
  • Reperfusion Injury* / etiology

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Supported by National Natural Science Foundation of China (61865014) and Inner Mongolia Autonomous Region science and technology program (2021GG0129).