Characterization of microRNA-223-3p as a novel promoter of cell proliferation and invasion in papillary thyroid carcinoma

Xinghe Pan; Junliang Liu; Yitong Zhang; Chenglin Sun; You Li; Hongpeng Guo

doi:10.1002/ccs3.12057

Characterization of microRNA-223-3p as a novel promoter of cell proliferation and invasion in papillary thyroid carcinoma

J Cell Commun Signal. 2024 Dec 19;19(1):e12057. doi: 10.1002/ccs3.12057. eCollection 2025 Mar.

Authors

Xinghe Pan¹, Junliang Liu¹, Yitong Zhang¹, Chenglin Sun¹, You Li¹, Hongpeng Guo¹

Affiliation

¹ Department of General Surgery Central Hospital Affiliated to Shenyang Medical College Shenyang Liaoning China.

Abstract

Papillary thyroid carcinoma (PTC), the most common thyroid cancer, has been linked to various molecular alterations. This study focuses on microRNA-223-3p, whose upregulated expression in PTC tissues appears to enhance tumor growth and cellular dysfunctions. Our findings demonstrate that microRNA-223-3p significantly promotes cell proliferation, invasion, and migration and induces epithelial-mesenchymal transition (EMT). Additionally, neurofibromatosis type 2 (NF2) is identified as a direct target, suggesting that microRNA-223-3p could be crucial in PTC pathogenesis and may offer a target for therapeutic intervention.

Keywords: cell proliferation; epithelial‐mesenchymal transition; microRNA‐223‐3p; neurofibromatosis type 2; papillary thyroid carcinoma; tumor invasion.