A Multifunctional Ru-Re Complex for Photodynamic Therapy and CO-Mediated Therapeutics in Alzheimer's Disease

Chun Hau Gan; Hsin-Jou Chen; Ricky Yu-Syun Fan; Siao-Cian Pan; Kien Voon Kong

doi:10.1002/chem.202403666

A Multifunctional Ru-Re Complex for Photodynamic Therapy and CO-Mediated Therapeutics in Alzheimer's Disease

Chemistry. 2024 Dec 23:e202403666. doi: 10.1002/chem.202403666. Online ahead of print.

Authors

Chun Hau Gan¹, Hsin-Jou Chen¹, Ricky Yu-Syun Fan¹, Siao-Cian Pan², Kien Voon Kong^{1

3}

Affiliations

¹ Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan.
² Immune Research Core, Department of Medical Research, National Taiwan University Hospital, No.7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City, 100225, Taiwan.
³ Center for Emerging Material and Advanced Devices, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan.

PMID: 39714883
DOI: 10.1002/chem.202403666

Abstract

The development of multifunctional therapeutic agents is crucial for addressing complex diseases such as Alzheimer's disease. Herein, we report a ruthenium-rhenium (Ru-Re) complex that combines photodynamic therapy (PDT) and carbon monoxide (CO) generation capabilities. The Ru-Re complex shows promising photophysical property and significant therapeutic potential. Our studies reveal the complex's ability to generate singlet oxygen (¹O₂), CO, inhibit tau aggregation, and enhance mitochondrial respiration. These multifunctional properties position the Ru-Re complex as a versatile tool for therapeutic applications in Alzheimer's disease.

Keywords: Alzheimer's disease; Carbon monoxide; Photosensitizers; Singlet oxygen.

Abstract

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