Alterations of Oscillatory Activity and Cognitive Function After Aneurysmal Subarachnoid Hemorrhage

Peng Liu; Chuanliang Han; Tongyu Zhang; Yueqiao Xu; Kun Yang; Yuxia Li; Zhennan Ye; Changming Wang; Hongqi Zhang

doi:10.1097/JS9.0000000000002190

Alterations of Oscillatory Activity and Cognitive Function After Aneurysmal Subarachnoid Hemorrhage

Int J Surg. 2024 Dec 24. doi: 10.1097/JS9.0000000000002190. Online ahead of print.

Authors

Peng Liu^{1

2}, Chuanliang Han³, Tongyu Zhang¹, Yueqiao Xu¹, Kun Yang⁴, Yuxia Li⁵, Zhennan Ye⁶, Changming Wang^{1

7}, Hongqi Zhang¹

Affiliations

¹ Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
² Department of Neurosurgery, Peking University Third Hospital, Peking University, Beijing, China.
³ School of Biomedical Sciences and Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong SAR, China.
⁴ Department of Epidemiology and Biostatistics, Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University School of Public Health, Beijing, China.
⁵ Department of Neurology, Tangshan central hospital, Tangshan, China.
⁶ Department of Neurosurgery, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou,, China.
⁷ Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, College of Biomedical Engineering, Capital Medical University, Beijing, China.

PMID: 39715156
DOI: 10.1097/JS9.0000000000002190

Abstract

Background: Aneurysmal subarachnoid hemorrhage (aSAH) can lead to cognitive impairment, but underlying neural mechanisms remain to be elucidated.

Materials and methods: To predict long-term cognitive impairment after aSAH, resting electroencephalography (EEG) was measured in 112 patients hospitalized with a diagnosis of aSAH (n = 66) or unruptured intracranial aneurysms (UIA; controls) (n = 46). A neuropsychological battery was administered 8 to 24 months after discharge.

Results: Power spectrum analysis in the parietal-occipital lobe showed significantly higher power theta vs. alpha oscillations in patients with cognitive impairment after aSAH. The power of theta and alpha oscillations were significantly correlated with multiple cognitive scale scores on the neuropsychological battery. A neural model was established, which showed that connectivity between inhibitory and excitatory neurons in neural circuits contributed to changes in theta and alpha oscillations and cognitive impairment in aSAH.

Conclusion: The data collection, analysis, and computational model established in this study can serve as a new paradigm for other clinical studies investigating cognitive impairment.