Fulminant Clostridioides (Costridium) difficile infection caused by a rare strain of PCR-ribotype 153 in Japan: A case report

Daichi Yomogida; Suguru Hasegawa; Shiori Mizuta; Shinjiro Horikawa; Yoshinao Koshida; Koichiro Matsuda; Masahiko Nakamura; Hiroyasu Kaya; Akio Uchiyama; Mitsutoshi Senoh

doi:10.1016/j.anaerobe.2024.102936

Fulminant Clostridioides (Costridium) difficile infection caused by a rare strain of PCR-ribotype 153 in Japan: A case report

Anaerobe. 2024 Dec 21:102936. doi: 10.1016/j.anaerobe.2024.102936. Online ahead of print.

Authors

Affiliations

¹ Department of Intensive Care Medicine. Electronic address: [email protected].
² Department of Intensive Care Medicine.
³ Department of Gastroenterology.
⁴ Department of Clinical laboratory.
⁵ Department of Infectious diseases.
⁶ Department of Pathology, Toyama Prefectural Central Hospital, Nishinagae2-2-78, Toyama city, Toyama, 930-8550, Japan.
⁷ Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.

PMID: 39716657
DOI: 10.1016/j.anaerobe.2024.102936

Abstract

Clostridioides (Clostridium) difficile (C. difficile) infection (CDI), often severe when producing toxin A, toxin B, and CDT, can cause life-threatening fulminant infections, especially in vulnerable patients. This case report discusses a 39-year-old woman with no medical history who developed severe CDI after antibiotic treatment, leading to fatal hypovolemic shock. A rare C. difficile PCR-ribotype 153 strain which is positive for toxin A, toxin B, and CDT was identified. This case emphasizes the need for early CDI diagnosis, cautious antibiotic use, and prompt treatment to prevent severe outcomes like shock and multiorgan failure.

Keywords: Antibiotic-associated diarrhea; Clostridioides (Clostridium) difficile; PCR-ribotype; binary toxin (CDT); fulminant Clostridioides (Clostridium) difficile infection.

Publication types

Case Reports