Tissierella Bacteremia in the Setting of Polymicrobial Osteomyelitis

We present a case of Tissierella bacteremia in the setting of polymicrobial osteomyelitis. Tissierella is a Gram-variable bacterium that has been rarely documented as the etiologic organism in human infections such as septic arthritis or otitis media, and even more rarely reported as an organism associated with bacteremia. The patient presented with septic shock and the physical exam was notable for gangrene of bilateral feet. Infectious workup was significant for acute osteomyelitis and septic arthritis of his feet in the setting of Tissierella bacteremia, which was successfully treated with piperacillin-tazobactam and then metronidazole in addition to surgical resection of the feet.