A multi-valent polymyxin-based fluorescent probe for the detection of Gram-negative infections

J Mater Chem B. 2024 Dec 24. doi: 10.1039/d4tb01786b. Online ahead of print.

Abstract

A multi-branched fluorogenic probe for the rapid and specific detection of Gram-negative bacteria is reported. Three Gram-negative-targeting azido-modified polymyxins were clicked onto a trivalent scaffold functionalised with the environmental green-emitting fluorophore 7-nitrobenz-2-oxa-1,3-diazole. The probe allowed wash-free detection of target bacteria with increased sensitivity and lower limits of detection compared to monovalent probes.