Recent advances targeting chemokines for breast cancer

Yanan Zhang; Xiufeng Tang; Ying Wang; Fengcui Shi; Xing Gao; Yingxin Guo; Qian Liu; Wenjian Ma

doi:10.1016/j.intimp.2024.113865

Recent advances targeting chemokines for breast cancer

Int Immunopharmacol. 2024 Dec 22:146:113865. doi: 10.1016/j.intimp.2024.113865. Online ahead of print.

Authors

Yanan Zhang¹, Xiufeng Tang², Ying Wang³, Fengcui Shi⁴, Xing Gao⁵, Yingxin Guo⁶, Qian Liu⁷, Wenjian Ma⁸

Affiliations

¹ College of Biological and Chemical Engineering, Qilu Institute of Technology, Shandong, China. Electronic address: [email protected].
² Department of Pharmacy and Shandong Provincinal Key Traditional Chinese Medical Discipline of Clinical Chinese Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong, China. Electronic address: [email protected].
³ College of Biological and Chemical Engineering, Qilu Institute of Technology, Shandong, China. Electronic address: [email protected].
⁴ College of Biological and Chemical Engineering, Qilu Institute of Technology, Shandong, China. Electronic address: [email protected].
⁵ College of Biological and Chemical Engineering, Qilu Institute of Technology, Shandong, China. Electronic address: [email protected].
⁶ College of Biological and Chemical Engineering, Qilu Institute of Technology, Shandong, China. Electronic address: [email protected].
⁷ College of Biological and Chemical Engineering, Qilu Institute of Technology, Shandong, China. Electronic address: [email protected].
⁸ College of Biological and Chemical Engineering, Qilu Institute of Technology, Shandong, China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China. Electronic address: [email protected].

PMID: 39718056
DOI: 10.1016/j.intimp.2024.113865

Abstract

Breast cancer (BC) is a complex and heterogeneous disease, and its onset and progression involve the interplay of multiple molecular mechanisms. Chemokines and their receptors are key regulators of cell migration and immune responses and contribute significantly to the pathophysiology of BC. This article reviews the classification, functions, and mechanisms of chemokines and their receptors in the proliferation, migration, invasion, and angiogenesis of BC cells. This study explores the regulatory roles of chemokines and their receptors in the immune microenvironment of BC, particularly the ways they influence the infiltration, polarization, and antitumor immune responses of immune cells. Finally, this article summarizes the current treatment strategies for breast cancer that utilize chemokines and their receptors and provides insights into future research directions and trends in this field.

Keywords: Anticancer therapy; Breast cancer; Chemokine.

Publication types

Review