Trends in syphilis case rates among women of reproductive age - United States, 2013-2022

We analyzed syphilis case notifications in reproductive age women during 2013-2022. Late/unknown duration syphilis grew faster after 2020 (45.8% versus 17.9% annual growth pre-2020). Increased screening, inaccurate staging, delayed diagnosis, or increased incidence following clinical and partner services gaps during 2020 may contribute to rises in late/unknown duration cases.