Shorter incubation period in symptomatic measles patients who had no history of measles vaccination

Hideo Tanaka; Yuki Takahashi; Sayuri Matsumoto; Miki Matsuyama; Koji Nakayama; Hiroshi Kodaira; Yoshinori Kubota; Juichi Kawakami; Takako Kurata; Daiki Kanbayashi; Kazushi Motomura

doi:10.1016/j.vaccine.2024.126652

Shorter incubation period in symptomatic measles patients who had no history of measles vaccination

Vaccine. 2024 Dec 22:45:126652. doi: 10.1016/j.vaccine.2024.126652. Online ahead of print.

Authors

Affiliations

¹ Public Health Center of Neyagawa City, 28-3 Yasakacho, Neyagawa, Osaka, Japan. Electronic address: [email protected].
² Health and Medical General Affairs Division of Osaka Prefectural Government, 1-22 Otemae 2-chome, Chuo-ku, Osaka, Osaka, Japan. Electronic address: [email protected].
³ Higashi-Osaka City Health Center, 4-3-22 Iwatacho, Higashi-osaka, Osaka, Japan. Electronic address: [email protected].
⁴ Higashi-Osaka City Health Center, 4-3-22 Iwatacho, Higashi-osaka, miki, Osaka, Japan. Electronic address: [email protected].
⁵ Osaka City Health Office, 1-2-7-1000 Asahimachi, Abeno-ku, Osaka, Osaka, Japan. Electronic address: [email protected].
⁶ Tamba Health and Welfare Office of Hyogo Prefectural Government, 688 Kaibara-cho, Kaibara, Tamba, Hyogo, Japan. Electronic address: [email protected].
⁷ Kamo Health Center of Gifu Prefectural Government, 2610-1 Shimokobi, Kobi-cho, Minokamo, Gifu, Japan. Electronic address: [email protected].
⁸ Kusatsu Health Center of Shiga Prefectural Government, 3-14-75 Kusatsu, Kusatsu, Shiga, Japan. Electronic address: [email protected].
⁹ Osaka Institute of Public Health, 1-3-3 Nakamichi, Higashinari-ku, Osaka, Osaka, Japan. Electronic address: [email protected].
¹⁰ Osaka Institute of Public Health, 1-3-3 Nakamichi, Higashinari-ku, Osaka, Osaka, Japan. Electronic address: [email protected].
¹¹ Osaka Institute of Public Health, 1-3-3 Nakamichi, Higashinari-ku, Osaka, Osaka, Japan. Electronic address: [email protected].

PMID: 39718292
DOI: 10.1016/j.vaccine.2024.126652

Abstract

In February 2024, a 22-year-old Japanese resident of Osaka Prefecture was diagnosed with measles in the PCR test. He had flown from Dubai to Osaka Kansai International Airport. We finally detected 13 incident measles cases identified as infected by the index case and collected data on these individuals to evaluate the association between vaccination and incubation period. The mean incubation period in all 13 infectees was 11.7 days (range: 7-20 days). The incubation period among infectees who had no history of measles vaccination ranged from 7 to 10 days (mean: 8.4 days), whereas it was significantly longer in those who had received any measles vaccine (p = 0.005). Moreover, the number of measles vaccinations received correlated positively with the length of the incubation period (p = 0.004).