Analysis of clinical characteristics and mortality risk factors in patients with community-acquired pneumonia caused by Klebsiella pneumoniae

Xiaofeng Yu; Lijun Suo; Xiao Sun; Tianyu Sun; Li Wang; Xiaowei Qi; Aiming Hou; Jiahui Luan; Haiyan Wang; Yi Zhao; Bo Liu; Hongyun Cao

doi:10.1016/j.diagmicrobio.2024.116660

Analysis of clinical characteristics and mortality risk factors in patients with community-acquired pneumonia caused by Klebsiella pneumoniae

Diagn Microbiol Infect Dis. 2024 Dec 16;111(3):116660. doi: 10.1016/j.diagmicrobio.2024.116660. Online ahead of print.

Authors

Xiaofeng Yu¹, Lijun Suo², Xiao Sun³, Tianyu Sun⁴, Li Wang⁴, Xiaowei Qi², Aiming Hou⁵, Jiahui Luan⁴, Haiyan Wang⁴, Yi Zhao⁴, Bo Liu⁴, Hongyun Cao⁶

Affiliations

¹ Department of Clinical Microbiology, Central Laboratory, Zibo City Key Laboratory of Respiratory Infection and Clinical Microbiology, Zibo Municipal Hospital, Zibo 255400, China.
² Department of Pulmonary and Critical Care Medicine, Zibo City Key Laboratory of Respiratory Infection and Clinical Microbiology, Zibo City Engineering Technology Research Center of Etiology Molecular Diagnosis, Zibo Municipal Hospital, Zibo 255400, China.
³ Research and Foreign Cooperation Department, Zibo Municipal Hospital, Zibo 255400, China.
⁴ Department of Clinical Microbiology, Pulmonary and Critical Care Medicine, Zibo City Key Laboratory of Respiratory Infection and Clinical Microbiology, Zibo City Engineering Technology Research Center of Etiology Molecular Diagnosis, Zibo Municipal Hospital, Zibo 255400, China.
⁵ Infection Management Department, Zibo Municipal Hospital, Zibo 255400, China.
⁶ Department of Clinical Microbiology, Pulmonary and Critical Care Medicine, Zibo City Key Laboratory of Respiratory Infection and Clinical Microbiology, Zibo City Engineering Technology Research Center of Etiology Molecular Diagnosis, Zibo Municipal Hospital, Zibo 255400, China. Electronic address: [email protected].

PMID: 39721109
DOI: 10.1016/j.diagmicrobio.2024.116660

Abstract

Community-acquired pneumonia (CAP) caused by Klebsiella pneumoniae (KP) results in high mortality. 121 cases were included in this study to explore the characteristics and risk factors of CAP patients caused by hypervirulent or resistant KP strains, which were limited reported in previous studies. We found that neither hypervirulent KP nor ESBL-producing KP infections affect mortality (P > 0.05), while increased qSOFA score (odds ratio [OR] 4.50, 95% confidence interval [CI] 1.55-12.76, P = 0.005) and APACHE-II score (OR 1.30, 95% CI 1.13-1.48, P < 0.001) were independent risk factors for mortality. In addition, the areas under the curve (AUCs) of qSOFA in predicting the mortality rate of all patients, ICU patients, and non-ICU patients were 0.82, 0.74, and 0.81, respectively. Elevated qSOFA or APACHE-II scores were considered independent risk factors for 28-day mortality. The qSOFA score was a good predictor of mortality among KP CAP patients.

Keywords: APACEH-II; Community-acquired pneumonia; ESBL-producing KP; Hypervirulent KP; qSOFA.