Case report: A successful live birth after in vitro fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively

Yifan Fan; Hui Song; Xu Chen; Pei Zhang; Jingwen Si; Hui Dong

doi:10.3389/fonc.2024.1461216

Case report: A successful live birth after in vitro fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively

Front Oncol. 2024 Dec 11:14:1461216. doi: 10.3389/fonc.2024.1461216. eCollection 2024.

Authors

Yifan Fan^{1

2

3}, Hui Song^{1

2

3}, Xu Chen^{1

2

3}, Pei Zhang¹, Jingwen Si¹, Hui Dong^{1

2

3}

Affiliations

¹ Department of Obstetrics and Gynecology, School of Medicine, Nankai University, Tianjin, China.
² Department of Obstetrics, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China.
³ Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China.

Abstract

Objective: To describe a patient conceiving with in vitro fertilization and embryo transfer(IVF-ET) after conservative treatment of early stage endometrial cancer.

Patient: A 31-year-old multiparous woman diagnosed with highly-differentiated (G1) endometrial adenocarcinoma (grade IA).

Interventions: After four courses of conservative treatment each followed by hysteroscopic biopsy and endometrial curettage,assisted reproductive technology was performed.

Main outcome measures: Successful pregnancy and delivery without residual endometrial cancer.

Resultss: A healthy normal female infant with a birth weight of 3,690 g was born by cesarean section at 38 + 2 weeks' gestation. No residual malignant cells was detected on a biopsy during cesarean section.

Conclusions: Conservative fertility-sparing treatment are crucial for young patients with early stage endometrial cancer. Assisted reproductive technologies may be considered to assist such patients to conceive as soon as possible.

Keywords: conservative treatment; early-stage endometrial cancer; fertility-sparing treatment; in vitro fertilization and embryo transfer; pregnancy.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Grants from the National Key Research and Development Program of China (Grant No. 2021YFC2701500) and Tianjin Key Medical Discipline(Specialty) Construction Project(TJYXZDXK-034A).