Injectable dual-network hyaluronic acid nanocomposite hydrogel for prevention of postoperative breast cancer recurrence and wound healing

Yu Zhang; Lixia Li; Xiaohe Jiang; Haimeng Liu; Xiaolu Guo; Hui Wu; Xiaohua Huang; Li Zhou; Chanjuan Liu; Xing-Can Shen

doi:10.1016/j.ijbiomac.2024.139125

Injectable dual-network hyaluronic acid nanocomposite hydrogel for prevention of postoperative breast cancer recurrence and wound healing

Int J Biol Macromol. 2024 Dec 24:291:139125. doi: 10.1016/j.ijbiomac.2024.139125. Online ahead of print.

Authors

Yu Zhang¹, Lixia Li¹, Xiaohe Jiang¹, Haimeng Liu¹, Xiaolu Guo², Hui Wu³, Xiaohua Huang¹, Li Zhou¹, Chanjuan Liu⁴, Xing-Can Shen²

Affiliations

¹ Guangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, College of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, PR China.
² State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541001, PR China.
³ College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China.
⁴ Guangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, College of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, PR China. Electronic address: [email protected].

PMID: 39725096
DOI: 10.1016/j.ijbiomac.2024.139125

Abstract

High locoregional recurrence rates and potential wound infections remain a significant challenge for postoperative breast cancer patients. Herein, we developed a dual-network hyaluronic acid (HA) nanocomposite hydrogel composed of herring sperm DNA (hsDNA) bridged methacrylated HA (HAMA) and FeMg-LDH-ppsa nanohybrid chelated catechol-modified HA (HADA) for the prevention of breast cancer recurrent, anti-infection, and promoting wound healing. Dynamic reversible hsDNA cross-linking combined with metal-catechol chelating renders the hydrogel injectability, rapid self-healing ability, and enhanced mechanical properties. FeMg-LDH-ppsa nanohybrids obtained by in situ polymerization of aniline derivatives in the FeMg-LDH interlayer exhibited excellent photothermal effect. Upon near-infrared (NIR) irradiation, the photothermal effect mediated by FeMg-LDH-ppsa can unwind the hsDNA duplex, enabling the controlled release of preloaded DOX for synergistic photothermal-chemotherapy antitumor. Meanwhile, the catechol-metal (Fe³⁺/Mg²⁺) moieties in the hydrogel enhanced tissue adhesion and exhibited intrinsic antimicrobial and bioactive properties, which in combination with the NIR-assisted photothermal effect, significantly accelerated infected wound healing through sterilizing microorganisms, alleviating inflammation, re-epithelialization, and angiogenesis. Overall, this multifunctional hydrogel represented a promising candidate in postoperative wound management for simultaneous tumor elimination, antiinfection, and wound repair.

Keywords: Dynamic dual-crosslinking network; NIR-triggered drug release; Photothermal nanohybrid; Postoperative tumor therapy; Space-confined polymerization.