Tumor metastasis and recurrence: The role of perioperative NETosis

Fu Zeng; Yuwen Shao; Jingyi Wu; Jingwen Luo; Ying Yue; Yang Shen; Yanghanzhao Wang; Yuxin Shi; Dan Wu; Juan P Cata; Shuofei Yang; Hao Zhang; Changhong Miao

doi:10.1016/j.canlet.2024.217413

Tumor metastasis and recurrence: The role of perioperative NETosis

Cancer Lett. 2024 Dec 24:611:217413. doi: 10.1016/j.canlet.2024.217413. Online ahead of print.

Authors

Fu Zeng¹, Yuwen Shao¹, Jingyi Wu², Jingwen Luo¹, Ying Yue¹, Yang Shen¹, Yanghanzhao Wang¹, Yuxin Shi¹, Dan Wu¹, Juan P Cata³, Shuofei Yang⁴, Hao Zhang⁵, Changhong Miao⁶

Affiliations

¹ Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China.
² Department of Anesthesiology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China.
³ Department of Anesthesiology and Perioperative Medicine, The University of Texas-MD Anderson Cancer Center, Houston, TX, USA; Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA.
⁴ Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pujian Road 160, Shanghai, 200127, China. Electronic address: [email protected].
⁵ Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. Electronic address: [email protected].
⁶ Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China. Electronic address: [email protected].

PMID: 39725150
DOI: 10.1016/j.canlet.2024.217413

Abstract

Although surgical resection of tumor mass remains the mainstay of curative therapeutic management for solid tumors, accumulating studies suggest that these procedures promote tumor recurrence and metastasis. Regarded as the first immune cells to fight against infectious or inflammatory insults from surgery, neutrophils along with their ability of neutrophil extracellular traps (NETs) production has attracted much attention. A growing body of evidence suggests that NETs promote cancer metastasis by stimulating various stages, including local invasion, colonization, and growth. Therefore, we discussed the mechanism of NETosis induced by surgical stress and tumor cells, and the contribution of NETs on tumor metastasis: aid in the tumor cell migration and proliferation, evasion of immune surveillance, circulating tumor cell adhesion and establishment of a metastatic niche. Lastly, we summarized existing NET-targeting interventions, offering recent insights into potential targets for clinical intervention.

Keywords: Metastasis; NETosis; Neutrophil extracellular traps; Surgery; Tumor.

Publication types

Review