The pathogenesis of obesity-associated kidney disease (OAKD) involves many aspects,including the overactivation of the renin-angiotensin-aldosterone system,insulin resistance,chronic inflammation,disorder of lipid metabolism and imbalance of gut microecology.Treatment strategies for OAKD focus on lifestyle adjustments,pharmacotherapy,bariatric surgery,and fecal microbiota transplantation.A deeper understanding of the hazards of OAKD and its pathogenesis will contribute to the development of personalized and precise strategies for prevention,diagnosis and treatment of OAKD in the future.
肥胖相关肾疾病的发病机制涉及多个方面,主要包括肾素-血管紧张素-醛固酮系统过度激活、胰岛素抵抗、慢性炎症、脂代谢紊乱及肠道微生态失衡等。针对肥胖相关肾疾病的治疗策略主要集中在生活方式的调整、药物治疗、减重手术及粪菌移植等。深入理解肥胖相关肾疾病的危害和明确其发病机制,将有助于未来开发个性化、精准化的预防、诊断和治疗一体化方案。.
Keywords: obesity; obesity-associated kidney disease; pathogenesis; treatment strategy.