The Prevalence and Genetic Characteristics of Porcine Circovirus Type 2 in Shandong Province, China, 2018-2020

Yuzhong Zhao; Xinyu Cui; Haotian Sang; Shaodong Wen; Lebin Han; Pingping Yang; Yihong Xiao; Yanmeng Hou

doi:10.3390/cimb46120809

The Prevalence and Genetic Characteristics of Porcine Circovirus Type 2 in Shandong Province, China, 2018-2020

Curr Issues Mol Biol. 2024 Nov 26;46(12):13542-13553. doi: 10.3390/cimb46120809.

Authors

Yuzhong Zhao^{1

2}, Xinyu Cui^{1

2}, Haotian Sang^{1

2}, Shaodong Wen^{1

2}, Lebin Han^{1

2}, Pingping Yang^{1

2}, Yihong Xiao^{1

2}, Yanmeng Hou^{1

2}

Affiliations

¹ College of Animal Science and Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an 271018, China.
² Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Tai'an 271018, China.

PMID: 39727937
DOI: 10.3390/cimb46120809

Abstract

Porcine circovirus type 2 (PCV2) is an important swine pathogen that has caused considerable economic losses in the global swine industry. During our surveillance of pigs in Shandong, China, from 2018 to 2020, we found that the PCV2 infection rate was 7.89% (86/1090). In addition, we found frequent mixed infections of PCV2 with porcine reproductive and respiratory syndrome virus (PRRSV), classical swine fever virus (CSFV), and porcine herpesvirus (PRV). Thirteen positive clinical samples were selected to amplify the complete genome of PCV2, and were sequenced. Among the 13, we detected two genotypes: PCV2b (1/13) and PCV2d (12/13). This suggests that PCV2d is the dominant genotype circulating in Shandong Province. Additionally, we found three positively selected sites in the ORF2 region, located on the previously reported antigenic epitopes. This investigation will contribute to understanding of the molecular epidemiology and genetic diversity of PCV2 strains in China.

Keywords: PCV2b; PCV2d; genetic diversity; infection; porcine circovirus.