A review on polysaccharide-based delivery systems for edible bioactives: pH responsive, controlled release, and emerging applications

pH changes occur during bodily lesions, presenting an opportunity for leveraging pH-responsive delivery systems as signals for a targeted response. This review explores the design and application of pH-responsive delivery systems based on natural polysaccharides for the controlled release of bioactives. The article examines the development of diverse delivery carriers, including nanoparticles, nanofibers, nanogels, core-shell carriers, hydrogels, emulsions as well as liposomes and their capacity to respond to pH variations, enabling the precise and targeted delivery of bioactives within the human body. These polysaccharide-based delivery systems can be made pH-responsive by modulating the charge of polybasic or polyacidic polysaccharides, inducing swelling of the carrier and subsequent release of the encapsulated bioactives. These pH-responsive systems show promise in stabilizing under acidic conditions for enhanced retention in the stomach during oral delivery while also enabling targeted release at low pH sites such as tumors and wounds, thereby accelerating wound healing and aiding in cancer therapy and inflammation treatment. pH can co-respond with a variety of stimuli, including temperature, enzymes and reactive oxygen species, enabling more precise responses to the microenvironment for targeted delivery. It provides solid theoretical foundations for the advancement of personalized nutrition and therapeutics through controlled and responsive release technologies.