Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain

Huiqiong Jia; Qingchao Tong; Le Wang; Yuye Wu; Xinyang Li; Shuangshuang Li; Yingying Kong; Yingying Zhang; João Pedro Rueda Furlan; Nwai Oo Khine; Patrick Butaye; Jun Zhang; Qing Yang; Zhi Ruan

doi:10.1016/j.drup.2024.101194

Silent circulation of plasmid-borne tet(X6) and bla_OXA-58 genes in a community-acquired Acinetobacter baumannii strain

Drug Resist Updat. 2024 Dec 25:79:101194. doi: 10.1016/j.drup.2024.101194. Online ahead of print.

Authors

Huiqiong Jia¹, Qingchao Tong², Le Wang³, Yuye Wu², Xinyang Li², Shuangshuang Li², Yingying Kong⁴, Yingying Zhang², João Pedro Rueda Furlan⁵, Nwai Oo Khine⁶, Patrick Butaye⁷, Jun Zhang⁸, Qing Yang⁹, Zhi Ruan¹⁰

Affiliations

¹ Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Key Laboratory of Clinical In Vitro Diagnostic Techniques, Hangzhou, China.
² Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
³ Department of Clinical Laboratory, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, China.
⁴ Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, China.
⁵ Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, São Paulo, Brazil.
⁶ Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary, City University of Hong Kong, Hong Kong, Hong Kong SAR, China.
⁷ Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary, City University of Hong Kong, Hong Kong, Hong Kong SAR, China; Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. Electronic address: [email protected].
⁸ Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, China. Electronic address: [email protected].
⁹ Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Key Laboratory of Clinical In Vitro Diagnostic Techniques, Hangzhou, China. Electronic address: [email protected].
¹⁰ Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, China. Electronic address: [email protected].

PMID: 39732137
DOI: 10.1016/j.drup.2024.101194

Abstract

To characterize the genomic features of a community-acquired Acinetobacter baumannii strain, co-carrying tet(X6) and bla_OXA-58 genes, but was susceptible to tigecycline and carbapenems. The tet(X6) and bla_OXA-58 genes were found on a 149,518 bp non-conjugative plasmid. The bla_OXA-58 gene was silent, due to the presence of an intact ISAba3-like element upstream, which rendered the strain susceptible to carbapenems.

Keywords: Acinetobacter baumannii; Antimicrobial resistance; Carbapenems; Plasmid; Tigecycline.