Three-dimensional printing-guided percutaneous transcatheter replacement in coarctation of the aorta: a retrospective study

Qing He; Chennian Xu; Yang Liu; Ping Jin; Mengen Zhai; Rui Qiao; Zhiyuan Tian; Bin Cui; Jian Yang

doi:10.3389/fcvm.2024.1429470

Three-dimensional printing-guided percutaneous transcatheter replacement in coarctation of the aorta: a retrospective study

Front Cardiovasc Med. 2024 Dec 13:11:1429470. doi: 10.3389/fcvm.2024.1429470. eCollection 2024.

Authors

Qing He^#¹, Chennian Xu^#^{1

2

3}, Yang Liu^#¹, Ping Jin¹, Mengen Zhai¹, Rui Qiao⁴, Zhiyuan Tian⁵, Bin Cui⁵, Jian Yang¹

Affiliations

¹ Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
² Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Air Force Medical University, Xi'an, Shaanxi, China.
³ Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
⁴ Department of 1st Cadre Ward, General Hospital of the Northern Theater Command, Shenyang, Liaoning, China.
⁵ The 79th Group Military Hospital of the Chinese People's Liberation Army, Liaoyang, Liaoning, China.

^# Contributed equally.

Abstract

Background: To evaluate the feasibility, effectiveness and assistant effect of 3D printed aortic model in the treatment on congenital coarctation of the aorta (CoA) in adolescents and adults.

Methods: From December 2018 to December 2023, a total of 10 patients with congenital coarctation of aorta underwent percutaneous balloon dilatation covered stent implantation in the department of cardiovascular surgery, Xijing Hospital. There were 6 males and 4 females whose average age was (27.68 ± 13.45) years. One case complicated with ventricular septal defect (VSD). The CT data of aorta were collected before operation, and the aorta was reconstructed by Mimics software and printed with 3D printing technology. The operation simulation was performed before operation to determine the best operation plan. The clinical data during hospitalization and follow-up were analyzed.

Results: All the patients of CoA were successfully treated with percutaneous balloon dilatation covered stent implantation. The narrowest average diameter of CoA increased from (4.35 ± 2.61) mm before operation to (16.84 ± 1.99) mm immediately after operation (P < 0.05). The mean transconstrictive systolic pressure difference decreased from (81.29 ± 18.72) mmHg before operation to (15.52 ± 7.47) mmHg after operation (P < 0.05). The mean systolic blood pressure of the right upper limb decreased from (182.05 ± 38.99) mmHg preoperatively to (141.95 ± 32.11) mmHg postoperatively (P < 0.05). The mean systolic blood pressure of the lower limb increased from (121.52 ± 27.84) mmHg preoperatively to (131.81 ± 32.39) mmHg postoperatively (P < 0.05). Two patients with PDA and VSD underwent interventional occlusion at the same time without shunt. During the period of hospitalization and follow-up, there were significant cardiovascular complications.

Conclusions: Percutaneous balloon dilatation covered stent implantation is effective in the treatment of adolescents and adults with CoA in the short and medium term, with fewer complications, and the long-term effect needs furthshdie1er study.

Keywords: 3D printing; coarctation of aorta; covered stent; interventional therapy; transcatheter replacement.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the National Key Research and Development Programs (2022YFC2503402), National Natural Science Foundation of China (82370375), Shaanxi Provincial Key Research and Development Plan (2023-YBSF-105), the 74th General Project of China Postdoctoral Science Foundation (2023M744296), Youth Project of Shaanxi Provincial Natural Science Basic Research Program (2024JC-YBQN-0793) and Start-up funding for postdoctoral research of Air Force Medical University (qd20230216).