Ni-Catalyzed Reductive Fluoroalkylthiolation of Alkynes toward Fluoroalkylated Vinylthioethers

Meng-Dan Wang; Ya-Nan Li; Lin-Xi Xiao; Run-Han Zhang; Meng Yuan; Zhao-Lun Wang; Xing-Guo Zhang; Hai-Yong Tu

doi:10.1021/acs.orglett.4c04434

Ni-Catalyzed Reductive Fluoroalkylthiolation of Alkynes toward Fluoroalkylated Vinylthioethers

Org Lett. 2025 Jan 1. doi: 10.1021/acs.orglett.4c04434. Online ahead of print.

Authors

Meng-Dan Wang¹, Ya-Nan Li¹, Lin-Xi Xiao¹, Run-Han Zhang¹, Meng Yuan¹, Zhao-Lun Wang¹, Xing-Guo Zhang^{1

2}, Hai-Yong Tu^{1

2}

Affiliations

¹ College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
² Lab of Biohealth Materials and Chemistry of Wenzhou, Wenzhou University, Wenzhou 325035, China.

PMID: 39742436
DOI: 10.1021/acs.orglett.4c04434

Abstract

A Ni-catalyzed protocol for the regioselective and stereoselective three-component fluoroalkylthiolation of alkynes with fluoroalkyl halides and thiosulfonates is presented. This reductive difunctionalization provides an efficient strategy for the rapid construction of fluoroalkyl-incorporated vinylthioethers under mild conditions in moderate to good yields.