Nocturnal and crepuscular fast-eyed insects often exploit multiple optical channels and temporal summation for fast and low-light imaging. Here, we report high-speed and high-sensitive microlens array camera (HS-MAC), inspired by multiple optical channels and temporal summation for insect vision. HS-MAC features cross-talk-free offset microlens arrays on a single rolling shutter CMOS image sensor and performs high-speed and high-sensitivity imaging by using channel fragmentation, temporal summation, and compressive frame reconstruction. The experimental results demonstrate that HS-MAC accurately measures the speed of a color disk rotating at 1950 rpm, recording fast sequences at 9120 fps with low noise equivalent irradiance (0.43 μW/cm2). Besides, HS-MAC visualizes the necking pinch-off of a pool fire flame in dim light conditions below one thousandth of a lux. The compact high-speed low-light camera can offer a distinct route for high-speed and low-light imaging in mobile, surveillance, and biomedical applications.