Suzuki-Miyaura/Mizoroki-Heck coupling cascade to access 2,2'-bifunctionalized biaryls

Chem Commun (Camb). 2025 Jan 2. doi: 10.1039/d4cc05763e. Online ahead of print.

Abstract

Biaryl motifs are essential structural features in several drugs and functional molecules. Cyclic diaryliodonium has been scarcely explored as a bifunctional agent compared to ring opening and annulation reactions. Herein, a three-component cascade approach is developed to synthesize bifunctionalized biaryls employing cyclic diaryliodoniums as a biarylating agent. The mild conditions enabled a vast array of biarylated products in good yields in a single step. Furthermore, preliminary mechanistic details and photophysical properties have been investigated.