The present-day treatment for advanced osteoarthritis is joint replacement. However, modern nonsurgical treatments have been used as a first-line option to delay or avoid arthroplasty, especially if treatments are started when osteoarthritis is moderate. Among many nonsurgical options, there has been an increased interest recently in the use of orthobiologics. Orthobiologics are natural substances harvested from one's own body and used to treat several conditions, such as arthritis, tendinopathies, bone healing, and others. Given these are relatively new therapies, there is limited evidence supporting their use. The most common emerging biologic strategies are discussed.