Impact of Social Determinants of Health on Cancer Treatment Referrals in Patients Living with HIV in the United States: A Narrative Review

Introduction: This narrative review aims to identify and explore the social determinants that prevent people living with HIV (PWH) from accessing specialized cancer centers in the United States and compare to patient experiences in other countries.

Methods: The review includes randomized controlled trials, cohort studies, case-control studies, qualitative studies, case series, and non-peer reviewed articles. The risk of bias was assessed using standardized tools, and data were synthesized narratively due to the heterogeneity of study designs and outcomes.

Results: Our findings highlight that PWH in the U.S. typically depend on public insurance or programs such as the Ryan White HIV/AIDS Program (RWHP), which offer better cancer care outcomes but are limited by income restrictions. Integrated health systems, such as Veterans Affairs (VA) centers, have successful cancer screening programs but limited accessibility. Limited health literacy among PWH is associated with poor clinical knowledge, misinterpretation of treatment outcomes, and underreporting of medical conditions. Although higher health literacy improves screening rates, its impact on referrals to specialized cancer centers is unclear. Racial and ethnic disparities result in lower screening rates and fewer referrals to specialized care, with Hispanic, Asian, and Black patients facing barriers like distrust in healthcare, cultural factors, and insurance status. HIV stigma further leads to healthcare avoidance and delayed interventions.

Conclusion: The review addresses systemic barriers including healthcare access, health literacy, racial, and ethnic disparities, and cultural stigma and highlights solutions to improve cancer treatment referrals among PWH. Recommendations include improving access to integrated health centers and developing culturally competent interventions to enhance referrals to advanced cancer care for PWH.