Interactive effects of air pollutants and viral exposure on daily influenza hospital visits in Mongolia

Yihui Ge; Yan Lin; Oyu Tsogtbayar; Ser-Od Khuyagaa; Eelin Khurelbaatar; Jargalsaikhan Galsuren; Lauren Prox; Shiyu Zhang; Robert M Tighe; Gregory C Gray; Junfeng Zhang; Daramragchaa Ulziimaa; Damdindorj Boldbaatar; Khurelbaatar Nyamdavaa; Davaalkham Dambadarjaa

doi:10.1016/j.envres.2024.120743

Interactive effects of air pollutants and viral exposure on daily influenza hospital visits in Mongolia

Environ Res. 2024 Dec 31:268:120743. doi: 10.1016/j.envres.2024.120743. Online ahead of print.

Authors

Affiliations

¹ Duke Nicholas School of the Environment, Durham, NC, 27705, USA.
² Duke Nicholas School of the Environment, Durham, NC, 27705, USA; Duke Global Health Institute, Durham, NC, 27705, USA.
³ School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar, 14210, Mongolia.
⁴ Department of Medicine, Duke University, Durham, NC, 27705, USA.
⁵ Department of Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA.
⁶ Mongolian National University of Medical Sciences, Ulaanbaatar, 14210, Mongolia.
⁷ Mongolian National University of Medical Sciences, Ulaanbaatar, 14210, Mongolia. Electronic address: [email protected].
⁸ School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar, 14210, Mongolia. Electronic address: [email protected].

PMID: 39746628
DOI: 10.1016/j.envres.2024.120743

Abstract

Background: Air pollution is a well-documented public health hazard linked to various adverse health outcomes. While studies have shown associations between elevated levels of air pollutants and increased influenza incidence, there is a notable knowledge gap concerning the interactive effects of air pollution and viral exposure on respiratory viral infections.

Objectives: This study sought to examine the interactive effects of air pollution and viral exposure on influenza hospital visits in Ulaanbaatar, Mongolia.

Methods: We conducted a time-series analysis linking daily hospital visits for influenza disease (defined as ICD10 diagnosis codes J11) with ambient concentrations of air pollutants (PM₁, PM_2.5, PM₁₀, NO₂, SO₂, and O₃) over a period of 7 years. Viral exposure for a specific geographical region was estimated based on influenza hospital visits within acute (previous day) and sub-acute (preceding 7 days) exposure windows. Covariates included long-term time trend, temperature, temperature variation, relative humidity, holiday, and raw coal ban policy. An over-dispersed generalized linear model (GLM) with a quasi-Poisson distribution was used to assess associations, exploring interactions and lag effects up to 3 days. Season-specific models and stratified analyses by sex and age were performed, with sensitivity analyses using multi-pollutant models.

Results: A total of 16,364 influenza hospital visits were recorded, with significantly higher rates of visits during the winter season. All six pollutants amplified the effects of viral exposure on hospital visits in cold months, while only PM₁, PM_2.5, and O₃ showed synergistic effects in warm months. Stronger synergistic effects were observed among children under 5 years old, particularly for O₃.

Conclusions: Air pollution significantly amplified the adverse effects of viral exposure on influenza-hospital visits, particularly among young children and during high viral exposure periods. These findings underscore the need for employing protective measures against both air pollution and viral infections.

Keywords: Air pollution; Influenza; Interaction effects.