One-year mortality and re-admission rate by disease etiology in National Heart Failure Registry of India

Nat Commun. 2025 Jan 2;16(1):275. doi: 10.1038/s41467-024-55362-z.

Abstract

Survival outcomes of patients with heart failure (HF) based on their disease etiology are not well described. Here, we provide one-year mortality outcomes of 10850 patients with HF (mean age = 59.9 years, 31% women) in India. Ischemic heart disease (71.9%), dilated cardiomyopathy (17.3), rheumatic heart disease (5.4), non-rheumatic valvular heart disease (1.9), hypertrophic cardiomyopathy (0.8), congenital heart disease (0.7), peri-partum cardiomyopathy (0.5), restrictive cardiomyopathy (0.4), and infective endocarditis (0.1) were the main disease etiologies. Mortality rate per 100-person years of follow-up varied from 13.8 (95% CI: 6.2-30.7) in peri-partum cardiomyopathy to 92.9 (46.5-185.9) in infective endocarditis. Compared to ischemic heart disease, the mortality was two to five times higher in rheumatic heart disease (HR = 2.0; 95% CI: 1.6-2.4), congenital heart disease (2.9; 1.9-4.2), and infective endocarditis (4.8; 2.4-9.8). The wide variations in mortality rate in HF patients may bring possible clinical applicability of risk stratification.

MeSH terms

  • Adult
  • Aged
  • Endocarditis / epidemiology
  • Endocarditis / mortality
  • Female
  • Heart Failure* / epidemiology
  • Heart Failure* / mortality
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Patient Readmission / statistics & numerical data
  • Registries*
  • Rheumatic Heart Disease / epidemiology
  • Rheumatic Heart Disease / mortality