Photoredox radical/polar crossover enables carbo-heterofunctionalization of alkenes: facile access to 1,3-difunctionalized nitro compounds

Chem Commun (Camb). 2025 Jan 3. doi: 10.1039/d4cc06005a. Online ahead of print.

Abstract

Herein, we present an efficient and practical method for multicomponent carbo-heterofunctionalization of alkenes via radical-polar crossover photoredox catalysis. Employing geminal bromonitroalkanes as redox-active reagents with a wide range of O-centered nucleophiles allows rapid access to various 1,3-difunctionalized nitro compounds, including β-nitro ketones, 1,3-nitro alcohols, 1,3-nitro ethers as well as cyclic molecules.