Sebaceous Carcinoma Arising in a Precursor Benign Sebaceoma: Rare Example Highlighting the Utility of Immunohistochemistry Including p53

Maged Daruish; Olubanji Oguntunde; Martyn Richards; Saleem Taibjee

doi:10.1097/DAD.0000000000002858

Sebaceous Carcinoma Arising in a Precursor Benign Sebaceoma: Rare Example Highlighting the Utility of Immunohistochemistry Including p53

Am J Dermatopathol. 2024 Nov 21. doi: 10.1097/DAD.0000000000002858. Online ahead of print.

Authors

Maged Daruish^{1

2}, Olubanji Oguntunde³, Martyn Richards⁴, Saleem Taibjee^{1

2}

Affiliations

¹ Cellular Pathology Department, Dorset County Hospital Foundation NHS Trust, Dorchester, United Kingdom.
² Poundbury Cancer Institute, Dorchester, United Kingdom.
³ Histopathology Department, Yeovil District Hospital, Somerset NHS Foundation Trust, Somerset, United Kingdom ; and.
⁴ Dermatology Department, Yeovil District Hospital, Somerset NHS Foundation Trust, Somerset, United Kingdom .

PMID: 39752247
DOI: 10.1097/DAD.0000000000002858

Abstract

Reports of sebaceous carcinoma arising from a pre-existing benign precursor are extremely sparse in the literature. We describe a case in which there was clear transition between sebaceoma and sebaceous carcinoma, with a different pattern of p53 staining in each component.