Deciphering the fate of replication-induced DNA double-strand breaks

Cody M Rogers; Patrick Sung

doi:10.1016/j.molcel.2024.12.006

Deciphering the fate of replication-induced DNA double-strand breaks

Mol Cell. 2025 Jan 2;85(1):3-4. doi: 10.1016/j.molcel.2024.12.006.

Authors

Cody M Rogers¹, Patrick Sung²

Affiliations

¹ Department of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address: [email protected].
² Department of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

PMID: 39753106
DOI: 10.1016/j.molcel.2024.12.006

Abstract

In this issue of Molecular Cell, studies by Xu et al.,¹ Kimble et al.,² and Elango et al.³ examine how yeast and mammalian cells process DNA double-strand breaks that arise when the DNA replication machinery encounters a DNA nick.

Publication types

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MeSH terms

Animals
DNA Breaks, Double-Stranded*
DNA Repair
DNA Replication*
Humans
Saccharomyces cerevisiae* / genetics
Saccharomyces cerevisiae* / metabolism