A novel mechanism promoting lipid droplet formation

Zheng Yang; Meng Zhang; Chang Du

doi:10.1016/j.tplants.2024.12.010

A novel mechanism promoting lipid droplet formation

Trends Plant Sci. 2025 Jan 3:S1360-1385(24)00346-7. doi: 10.1016/j.tplants.2024.12.010. Online ahead of print.

Authors

Zheng Yang¹, Meng Zhang², Chang Du³

Affiliations

¹ Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China; Zhengzhou Research Base, National Key Laboratory of Cotton Bio-breeding and Integrated Utilization, School of Agricultural Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China.
² College of Agronomy, Northwest A&F University, Yangling, Shaanxi 712100, China.
³ Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China. Electronic address: [email protected].

PMID: 39755455
DOI: 10.1016/j.tplants.2024.12.010

Abstract

Recently, Torres-Romero et al. identified a novel lipid droplet (LD)-associated protein, α/β-hydrolase domain containing protein 1 (ABHD1), in algae. Structurally, ABHD1 promotes the budding and growth of LDs and, functionally, it hydrolyzes lyso-diacylglyceryl-N,N,N-trimethylhomoserine (lyso-DGTS) to generate glyceryl-N,N,N-trimethylhomoserine (GTS) and free fatty acids (FFAs). Taken together, ABHD1 mediates a novel pathway for LD formation.

Keywords: ABHD1; lipid droplets; lyso-DGTS; triacylglycerol.