The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer

John Y Kwon; Renzo E Vera; Martin E Fernandez-Zapico

doi:10.1016/j.cellsig.2024.111584

The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer

Cell Signal. 2025 Jan 3:111584. doi: 10.1016/j.cellsig.2024.111584. Online ahead of print.

Authors

John Y Kwon¹, Renzo E Vera², Martin E Fernandez-Zapico³

Affiliations

¹ Schulze Center for Novel Therapeutics, Division of Oncology Research, Rochester, MN 55901, USA. Electronic address: [email protected].
² Schulze Center for Novel Therapeutics, Division of Oncology Research, Rochester, MN 55901, USA. Electronic address: [email protected].
³ Schulze Center for Novel Therapeutics, Division of Oncology Research, Rochester, MN 55901, USA. Electronic address: [email protected].

PMID: 39756502
DOI: 10.1016/j.cellsig.2024.111584

Abstract

The tumor microenvironment (TME) has been linked with the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), the most common histological subtype of pancreatic cancer. A central component of the TME are cancer-associated fibroblasts (CAFs), which can either suppress or promote tumor growth in a context-dependent manner. In this review, we will discuss the multi-faceted roles of CAFs in tumor-stroma interactions influencing cancer initiation, progression and therapeutic response.

Keywords: Cancer associated fibroblasts; PDAC; Stroma; Tumor microenvironment.

Publication types

Review