Approaches to regenerative endodontic therapy in necrotic human teeth with complete root formation: a systematic review

Introduction: Regenerative endodontic procedures (REPs) aim to replace damaged dental structures and regenerate the dentin-pulp complex. Initially focused on teeth with incomplete root formation, recent research shows promise for necrotic teeth with complete root formation.

Methodology: This review, following PRISMA guidelines and registered in PROSPERO, included clinical studies on regenerative endodontic therapy in necrotic human teeth with complete root formation. Searches in PubMed, Web of Science, Embase, and Cochrane Library identified 10 studies meeting the criteria.

Results: The studies showed variable regenerative endodontic protocols and materials, with success rates ranging from 60 to 100%. Most studies reported favorable outcomes, such as symptom resolution and bone healing.

Discussion: Regenerative endodontic therapy for necrotic teeth with complete root formation shows high success rates, but the variability in protocols calls for standardized guidelines and further high-quality trials.

Conclusion: Regenerative endodontic therapy is a promising alternative to conventional treatments for necrotic teeth with complete root formation, with demonstrated potential for restoring pulp vitality.Future research should optimize protocols and materials for consistent success.