Heparin Versus Saline: A Comparative Study to Support Practice Change Within an Organization

J Infus Nurs. 2025 Jan-Feb;48(1):11-16. doi: 10.1097/NAN.0000000000000569. Epub 2024 Dec 26.

Abstract

This nurse-led research study investigates the comparative effectiveness of heparin versus 0.9% sodium chloride locking in blood cancer patients with peripherally inserted central catheters (PICCs). Subjects were randomly assigned to receive either heparin or 0.9% sodium chloride locking for up to 7 days. Results show no significant difference in maintaining the PICCs' patency between the 2 locking methods. Additionally, heparin was associated with more side effects, higher costs, and increased nursing time compared to 0.9% sodium chloride. These findings support adopting 0.9% sodium chloride for PICC maintenance in blood cancer patients, aiming to enhance patient safety and reduce costs.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Anticoagulants / administration & dosage
  • Anticoagulants / therapeutic use
  • Catheterization, Central Venous
  • Catheterization, Peripheral
  • Female
  • Heparin* / administration & dosage
  • Humans
  • Male
  • Middle Aged
  • Saline Solution / administration & dosage
  • Sodium Chloride / administration & dosage

Substances

  • Heparin
  • Saline Solution
  • Anticoagulants
  • Sodium Chloride