Metabolomics Revealed Cadmium Exposure Associated with Alterations in Serum Metabolism in Children

Cadmium is a heavy metal contaminant known to cause various health issues. However, limited research exists on the serum metabolomic effects of cadmium exposure in children. In this study, we recruited 42 children to analyze their serum metabolomic profiles, along with measuring urinary cadmium and creatinine concentrations, to evaluate the impact of environmental cadmium exposure on serum metabolism. We also screened for potential biomarkers. The findings revealed that environmental cadmium exposure led to disruptions in amino acid metabolism, biosynthesis of secondary metabolites, endocrine function, lipid metabolism, nervous system function, sensory processes, and the metabolism of cofactors and vitamins in children. Lansioside C, Hydroxytanshinone, and 1-Methylinosine were identified as potential biomarkers. In conclusion, environmental cadmium exposure negatively impacts children's neurological development by inducing metabolic disturbances and increasing the risk of oxidative stress-related disorders. This study provides a valuable theoretical foundation for future efforts to prevent the harmful effects of cadmium exposure in children and mitigate associated health risks.